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Expert Opin Investig Drugs 2001 10:943-954.ĭe Denus S, O'Meara E, Desai AS, Claggett B, Lewis EF, Leclair G, Jutras M, Lavoie J, Solomon SD, Pitt B, Pfeffer MA, Rouleau JL. Systolic blood pressure and cardiovascular outcomes in heart failure with preserved ejection fraction: an analysis of the TOPCAT trial. Selvaraj S, Claggett B, Shah SJ, Anand I, Rouleau JL, Desai AS, Lewis EF, Pitt B, Sweitzer NK, Pfeffer MA, Solomon SD. Regional variation in patients and outcomes in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. Pfeffer MA, Claggett B, Assmann SF, Boineau R, Anand IS, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Heitner JF, Lewis EF, O'Meara E, Rouleau JL, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, McKinlay SM, Pitt B. Spironolactone for heart failure with preserved ejection fraction. Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O'Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM TOPCAT Investigators. In TOPCAT Americas, the benefit of spironolactone on outcomes could not be solely attributed to potential diuretic effects, suggesting the presence of non-diuretic mechanisms.ĭiuretics Heart failure with preserved ejection fraction Hospitalizations Spironolactone. Results were similar for cardiovascular mortality and time to first HF hospitalization. However, the effect of spironolactone on HF hospitalizations persisted (HR 0.77 95% CI 0.62-0.96 P = 0.021) in these models. In time-updated models, loop diuretic dose, creatinine (HR per doubling 1.28 95% CI 1.04-1.40 P = 0.019), and ACEI/ARB use (HR 0.82 95% CI 0.67-1.00 P = 0.048) were associated with HF hospitalizations.

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Serum creatinine increased more with spironolactone (+12.5% vs. : Top Cat - The Complete Series : Arnold Stang, Allen Jenkins, Maurice Gosfield, Lonette McKee, John Stephenson, Marvin Kaplan, Leo DeLyon. +1.7% P = 0.003) decreased with spironolactone however, angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) use decreased also (-13.1% vs. Daily furosemide dose (time-averaged Δ: -4.8% vs. Despite more weight loss with spironolactone initially, weight trajectories overlapped after 12 months.

There were 800 HF hospitalizations after a median of 3.0 years.

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We used mixed-effects models for serial data and shared frailty models to identify determinants of recurrent HF hospitalizations among baseline and serial parameters. We analysed data from TOPCAT Americas (1767 patients with HF and preserved ejection fraction 886 in spironolactone, 881 in placebo arm). We examined the effects of spironolactone on weight, diuretic use, and renal function, and their subsequent impact on outcomes.

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#PiratesCove -> To avoid fakes, ALWAYS check that the torrent was added on ExtraTorrents.It is unclear whether spironolactone reduced heart failure (HF) hospitalizations in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial through potential diuretic or other effects. f42d4e2d88 FSX - P3D - P3D2 Topcat 2.74 Beta (Cracked) Magnet link This torrent has 7 comments.

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It's good that a cat has nine lives, because with Top Cat's talent for trouble, he needs every one! Always just one leap ahead of Officer Dibble, this furry tornado of comic action is abetted by his fellow alley cats, who can never resist partaking in Top Cat's next humorous hustle. Strutting his stuff as the most charming, conniving con cat to ever rule the alleys of New York City, Top Cat plots one screwball strategy after another in his constant quest to turn a fast buck.